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442,443 A randomized controlled trial in 52 women with major depression found combined treatment with escitalopram plus creatine monohydrate, at 3 grams daily for one week followed by 5 grams daily for seven weeks, led to better treatment responsiveness than escitalopram plus placebo

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Mild Nausea or Bloating If you take a supplement that your body finds difficult to break down, you might experience a heavy feeling in the stomach or mild nausea

The alterations in serotonin function might have been present before the drug use began, they might even have contributed to the start of drug use or they might be purely coincidental